A blizzard forces the mismatched group to seek refuge at Minnie’s Haberdashery, a stagecoach stopover. However, when they arrive, they find the familiar faces of Minnie missing, replaced by four unfamiliar men: Bob (a Mexican caretaker), Oswaldo Mobray (a British hangman), Joe Gage (a quiet cowboy), and General Sanford Smithers (a Confederate general). As the storm rages outside, paranoia, betrayal, and explosive violence unravel inside.