Gopika began her acting career in the early 2000s, making her debut in the Malayalam film industry with the movie "Asha Madhavan" (2002). However, it was her breakout role in the 2004 film "Iruvar" that catapulted her to fame. Her on-screen chemistry with co-star Murali was undeniable, and their romantic storyline in the film earned her a massive fan following.