If your Mac detects the hardware but no sound is produced, try this manual configuration: Open Audio MIDI Setup (located in /Applications/Utilities ). Go to Window > Show MIDI Studio . Add Device (+) button and name it "
The M-Audio Radium 49 is a "Class Compliant" device for basic MIDI notes, but to use the advanced features (assignable knobs, faders, and the "Advanced" button functions), it historically required a specific driver from M-Audio.
: Some older M-Audio devices struggle with the lower power output of modern Mac ports; using a powered USB 2.0 hub can sometimes stabilize the connection. M-Audio Radium 49 driver macOS Ventura
For 80% of users who just need a simple keyboard to play virtual instruments, However, for those who bought the Radium specifically for its hands-on controller surface, you need a workaround.