Most modern mods for the Resident Evil 4 Remake or the original UHD version are managed via specialized tools to prevent file corruption.
Get the latest layout.bin from Nexus Mods. Look for files uploaded within the last —that’s your “hot” version. layoutbin file for resident evil 4 hot
For those interested in exploring layoutbin files further, here are some additional resources: Most modern mods for the Resident Evil 4