Yes. The serializer is architecture-agnostic and works flawlessly on Apple Silicon Macs running Office 2021 (which has native Apple Silicon support).
The command is deceptively simple:
As one higher-ed sysadmin told us: “We use the VL Serializer to keep our computer labs functional. But every summer, we re-image 800 Macs. The Serializer is just the first step in a longer dance.” microsoft office 2021 vl serializer mac
Microsoft grants "Re-Imaging Rights" under Volume Licensing. This allows microsoft office 2021 vl serializer mac
It provides native support for both Apple Silicon (M-series chips) and Intel-based Macs. It requires Office version 16.53 or later to function correctly. Acquisition & Deployment microsoft office 2021 vl serializer mac